Naturally selected hepatitis C virus polymorphisms confer broad neutralizing antibody resistance
نویسندگان
چکیده
منابع مشابه
Naturally selected hepatitis C virus polymorphisms confer broad neutralizing antibody resistance.
For hepatitis C virus (HCV) and other highly variable viruses, broadly neutralizing mAbs are an important guide for vaccine development. The development of resistance to anti-HCV mAbs is poorly understood, in part due to a lack of neutralization testing against diverse, representative panels of HCV variants. Here, we developed a neutralization panel expressing diverse, naturally occurring HCV e...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2014
ISSN: 0021-9738
DOI: 10.1172/jci78794